Osteoarthritis and Risk of Death: A Leading Cause of Cardiotoxicity
Results from a cohort of 104 elderly patients and 49 healthy subjects showed that patients with FKW had significantly lower than predicted risk values for all-cause mortality and cardiovascular disease mortality associated with the development of ARDS.Study authors reported that unpublished data suggest that their analysis excluding patients with ARDS is consistent with the findings of the 6-month body mass index (BMI) scanning program being conducted in the Framingham Heart Study of children and young adults.
The researchers then explored the indirect effects of BMI on participants’ risk of death at six-month follow-up from their assessments, finding a borderline significant negative influence with no clear adverse effects.
“With obesity, FKW and similar syndromes have been well-studied for its potential role in diseases of the musculoskeletal system and its risk prediction for these diseases,” explained Alexey Oshbayev, MD, Ph.D., MPH, assistant professor of pediatrics at the University of Pennsylvania Perelman School of Medicine and senior research associate at the Center for Pediatric Injury Research (CPIR) at the University of Pennsylvania, Philadelphia, PA, and senior research scholar at the National Institute of Environmental Health Sciences in Greece.
This finding suggests that there is a role for FKW in the outcome of patients with ARDS.”
Subjects most affected by ARDS, and with a BMI of between 25 and 33, displayed lower risk scores for ARDS:a 9-point risk adjusted by 0.05 kg/m2b 4-point risk adjusted by 0.06 kg/m2b 7-point risk adjusted by 0.06 kg/m2c 10-point risk adjusted by 0.06 kg/m2d 25-point risk adjusted by 0.04 kg/m2d and 30-point risk adjusted by 0.03 kg/m2d